InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rfxank

Summary

InnateDB Protein

IDBP-161752.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rfxank

Protein Name

regulatory factor X-associated ankyrin-containing protein

Synonyms

Tvl1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000075140

InnateDB Gene

IDBG-161750 (Rfxank)

Protein Structure

UniProt Annotation

Function

Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator (CIITA). May regulate other genes in the cell (By similarity). Potentiates the activation of RAF-1. RFX binds the X1 box of MHC-II promoters. {ECO:0000250}.

Subcellular Localization

Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

Expressed primarily in thymus, lung and testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0042826	histone deacetylase binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0007265	Ras protein signal transduction
GO:0045944	positive regulation of transcription from RNA polymerase II promoter