Version 5.4
Mus musculus Gene: Eda
Summary
InnateDB Gene IDBG-161929.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eda
Gene Name ectodysplasin-A
Synonyms Ed1; Eda-A1; Eda-A2; EDA1; HED; Ta; tabby; XLHED
Species Mus musculus
Ensembl Gene ENSMUSG00000059327
Encoded Proteins
IDBP-161931
ectodysplasin-A
IDBP-253148
ectodysplasin-A
IDBP-253150
ectodysplasin-A
IDBP-253152
ectodysplasin-A
IDBP-253154
ectodysplasin-A
IDBP-253156
ectodysplasin-A
IDBP-253158
ectodysplasin-A
IDBP-253160
ectodysplasin-A
IDBP-253162
ectodysplasin-A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158813:
The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:99975606-100400762
Strand Forward strand
Band C3
Transcripts
ENSMUST00000071453 ENSMUSP00000071397
ENSMUST00000113783 ENSMUSP00000109413
ENSMUST00000113781 ENSMUSP00000109411
ENSMUST00000113780 ENSMUSP00000109410
ENSMUST00000113779 ENSMUSP00000109409
ENSMUST00000113778 ENSMUSP00000109408
ENSMUST00000113777 ENSMUSP00000109407
ENSMUST00000113776 ENSMUSP00000109406
ENSMUST00000113775 ENSMUSP00000109405
ENSMUST00000134582
ENSMUST00000145063
ENSMUST00000123547
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005164 tumor necrosis factor receptor binding
GO:0005515 protein binding
Biological Process
GO:0001942 hair follicle development
GO:0006955 immune response
GO:0007160 cell-matrix adhesion
GO:0010467 gene expression
GO:0030154 cell differentiation
GO:0042346 positive regulation of NF-kappaB import into nucleus
GO:0042475 odontogenesis of dentin-containing tooth
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043473 pigmentation
GO:0043588 skin development
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060662 salivary gland cavitation
GO:0060789 hair follicle placode formation
GO:0061153 trachea gland development
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005581 collagen trimer
GO:0005789 endoplasmic reticulum membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0045177 apical part of cell
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000158813
View Gene Order
ENSBTAG00000012543
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.328086
RefSeq NM_001177937 NM_001177938 NM_001177939 NM_001177940 NM_001177941 NM_001177942 NM_001177943 NM_001177944 NM_010099 XM_006527778
OMIM
CCDS CCDS30299 CCDS53141 CCDS53142 CCDS53143 CCDS53144 CCDS53145
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca