Version 5.4
Mus musculus Gene: Pcdh15
Summary
InnateDB Gene IDBG-162009.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pcdh15
Gene Name protocadherin 15
Synonyms av; BB078305; ENSMUSG00000046980; Gm9815; nmf19; Ush1f
Species Mus musculus
Ensembl Gene ENSMUSG00000052613
Encoded Proteins
IDBP-162011
protocadherin 15
IDBP-162013
protocadherin 15
IDBP-270898
protocadherin 15
IDBP-270904
protocadherin 15
IDBP-270908
protocadherin 15
IDBP-712406
IDBP-538849
protocadherin 15
IDBP-532408
protocadherin 15
IDBP-536203
protocadherin 15
IDBP-537988
protocadherin 15
IDBP-538522
protocadherin 15
IDBP-535663
protocadherin 15
IDBP-534609
protocadherin 15
IDBP-532082
protocadherin 15
IDBP-534975
protocadherin 15
IDBP-537224
protocadherin 15
IDBP-710854
IDBP-534339
protocadherin 15
IDBP-532034
protocadherin 15
IDBP-535152
protocadherin 15
IDBP-532354
protocadherin 15
IDBP-540671
protocadherin 15
IDBP-539030
protocadherin 15
IDBP-710592
IDBP-714423
IDBP-711332
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000150275:
This gene is a member of the cadherin superfamily. Family members encode integral membrane proteins that mediate calcium-dependent cell-cell adhesion. It plays an essential role in maintenance of normal retinal and cochlear function. Mutations in this gene result in hearing loss and Usher Syndrome Type IF (USH1F). Extensive alternative splicing resulting in multiple isoforms has been observed in the mouse ortholog. Similar alternatively spliced transcripts are inferred to occur in human, and additional variants are likely to occur. [provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:73099342-74646314
Strand Forward strand
Band B5.3
Transcripts
ENSMUST00000092420 ENSMUSP00000090076
ENSMUST00000064562 ENSMUSP00000068561
ENSMUST00000105429 ENSMUSP00000101069
ENSMUST00000105426 ENSMUSP00000101066
ENSMUST00000105424 ENSMUSP00000101064
ENSMUST00000123398
ENSMUST00000148572
ENSMUST00000156999
ENSMUST00000146682 ENSMUSP00000134863
ENSMUST00000136096 ENSMUSP00000121534
ENSMUST00000124046 ENSMUSP00000121130
ENSMUST00000131724 ENSMUSP00000122466
ENSMUST00000152655 ENSMUSP00000118201
ENSMUST00000149977 ENSMUSP00000118833
ENSMUST00000151116 ENSMUSP00000119662
ENSMUST00000147189 ENSMUSP00000122940
ENSMUST00000126920 ENSMUSP00000121939
ENSMUST00000131321 ENSMUSP00000122911
ENSMUST00000129404 ENSMUSP00000117731
ENSMUST00000155701 ENSMUSP00000135495
ENSMUST00000152819 ENSMUSP00000123647
ENSMUST00000125517 ENSMUSP00000115399
ENSMUST00000125055 ENSMUSP00000114326
ENSMUST00000125006 ENSMUSP00000120056
ENSMUST00000134009 ENSMUSP00000120618
ENSMUST00000147455
ENSMUST00000139106
ENSMUST00000128843
ENSMUST00000144302 ENSMUSP00000122606
ENSMUST00000127928
ENSMUST00000177420 ENSMUSP00000135849
ENSMUST00000177107 ENSMUSP00000135501
ENSMUST00000177128 ENSMUSP00000135888
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0001964 startle response
GO:0002009 morphogenesis of an epithelium
GO:0007015 actin filament organization
GO:0007156 homophilic cell adhesion
GO:0007601 visual perception
GO:0007605 sensory perception of sound
GO:0007626 locomotory behavior
GO:0007628 adult walking behavior
GO:0035058 nonmotile primary cilium assembly
GO:0035264 multicellular organism growth
GO:0042491 auditory receptor cell differentiation
GO:0048839 inner ear development
GO:0050910 detection of mechanical stimulus involved in sensory perception of sound
GO:0050973 detection of mechanical stimulus involved in equilibrioception
GO:0060013 righting reflex
GO:0060088 auditory receptor cell stereocilium organization
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0032420 stereocilium
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000150275
View Gene Order
ENSBTAG00000045905
Not yet available
Cross-References
SwissProt Q99PJ1
TrEMBL
UniProt Splice Variant
Entrez Gene 11994
UniGene Mm.338933 Mm.408656 Mm.479473
RefSeq NM_001142741 NM_001142735 NM_001142736 NM_001142737 NM_001142738 NM_001142739 NM_001142740 NM_001142742 NM_001142743 NM_001142746 NM_001142747 NM_001142748 NM_001142760 NM_023115 XM_006513143 XM_006513144 XM_006513145 XM_006513146 XM_006513147 XM_006513148 XM_006513149 XM_006513150 XM_006513151 XM_006513153 XM_006513155 XM_006513156 XM_006513157 XM_006513158
OMIM
CCDS CCDS56721 CCDS35934 CCDS48594 CCDS48595 CCDS56711 CCDS56712 CCDS56713 CCDS56714 CCDS56715 CCDS56716 CCDS56717 CCDS56718 CCDS56719 CCDS56720
HPRD
IMGT
MGI ID MGI:1891428
MGI Symbol Pcdh15
EMBL AC108392 AC119894 AC121142 AC121602 AC121832 AC123032 AC123809 AC144802 AC147721 AC153858 AC158800 AC159477 AC186813 AC188091 AF281899 AK139154 AK141024 AY949849 CAAA01110489 DQ354396 DQ354397 DQ354398 DQ354399 DQ354400 DQ354401 DQ354402 DQ354403 DQ354404 DQ354405 DQ354406 DQ354407 DQ354408 DQ354409 DQ354410 DQ354411 DQ354412 DQ354413 DQ354414 DQ354415 DQ354416 DQ354417 DQ354418 HQ404375 HQ420254
GenPept AAG53891 AAY24693 ABC79259 ABC79260 ABC79261 ABC79262 ABC79263 ABC79264 ABC79265 ABC79266 ABC79267 ABC79268 ABC79269 ABC79270 ABC79271 ABC79272 ABC79273 ABC79274 ABC79275 ABC79276 ABC79277 ABC79278 ABC79279 ABC79280 ABC79281 ADP09331 ADT91308 BAE23903 BAE24546
RNA Seq Atlas 11994

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca