Version 5.4
Mus musculus Gene: Galc
Summary
InnateDB Gene IDBG-162136.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Galc
Gene Name galactosylceramidase
Synonyms 2310068B06Rik; A930008M05Rik; AW212969; AW413532; Gacy; twi; twitcher
Species Mus musculus
Ensembl Gene ENSMUSG00000021003
Encoded Proteins
IDBP-162138
galactosylceramidase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000054983:
This gene encodes a lysosomal protein which hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Mutations in this gene have been associated with Krabbe disease, also known as globoid cell leukodystrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:98202304-98259459
Strand Reverse strand
Band E
Transcripts
ENSMUST00000021390 ENSMUSP00000021390
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004336 galactosylceramidase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006683 galactosylceramide catabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005764 lysosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000054983
View Gene Order
ENSBTAG00000001124
Not yet available
Pathways
NETPATH
REACTOME
REACT_199008
Glycosphingolipid metabolism pathway
REACT_188937
Metabolism pathway
REACT_245163
Sphingolipid metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
KEGG
mmu00600
Sphingolipid metabolism pathway
mmu04142
Lysosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_116105
Glycosphingolipid metabolism pathway
REACT_19323
Sphingolipid metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00600
Sphingolipid metabolism pathway
hsa04142
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt P54818
TrEMBL
UniProt Splice Variant
Entrez Gene 14420
UniGene
RefSeq NM_008079
OMIM
CCDS CCDS36517
HPRD
IMGT
MGI ID MGI:95636
MGI Symbol Galc
EMBL AF003870 AF003871 AF003872 AF003873 AF003874 AF003875 AF003876 AF003877 AF003878 AF003879 AF003880 AF003881 AF003882 AF003883 AF003884 AF003885 AF003886 AK154760 BC086671 CH466549 D38557
GenPept AAB71823 AAH86671 BAA07560 BAE32809 EDL18937
RNA Seq Atlas 14420

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca