InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Homer3

Summary

InnateDB Gene

IDBG-162318.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Homer3

Gene Name

homer homolog 3 (Drosophila)

Synonyms

AW146114

Species

Mus musculus

Ensembl Gene

ENSMUSG00000003573

Encoded Proteins

IDBP-162320

homer homolog 3 (Drosophila)

IDBP-162322

homer homolog 3 (Drosophila)

IDBP-260942

homer homolog 3 (Drosophila)

IDBP-537656

homer homolog 3 (Drosophila)

IDBP-716875

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000051128:
This gene encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. The encoded protein binds numerous other proteins including group I metabotropic glutamate receptors, inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and trafficking of amyloid beta peptides. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:70282827-70294361

Strand

Forward strand

Band

B3.3

Transcripts

ENSMUST00000003669	ENSMUSP00000003669
ENSMUST00000087467	ENSMUSP00000084735
ENSMUST00000110124	ENSMUSP00000105751
ENSMUST00000140212	ENSMUSP00000117033
ENSMUST00000155711
ENSMUST00000143528
ENSMUST00000135692
ENSMUST00000135368	ENSMUSP00000137560

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0019904	protein domain specific binding

Biological Process

GO:0007216

G-protein coupled glutamate receptor signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0014069	postsynaptic density
GO:0030054	cell junction
GO:0045178	basal part of cell
GO:0045211	postsynaptic membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000051128

View Gene Order

ENSBTAG00000000813

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_11

TCR pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

26558

UniGene

RefSeq

NM_001146153 NM_011984 XM_006509679 XM_006509680

OMIM

CCDS

CCDS22363 CCDS52569

HPRD

IMGT

MGI ID

MGI:1347359

MGI Symbol

Homer3

EMBL

GenPept

RNA Seq Atlas

26558