InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Homer3

Summary

InnateDB Protein

IDBP-537656.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Homer3

Protein Name

homer homolog 3 (Drosophila)

Synonyms

AW146114;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000117033

InnateDB Gene

IDBG-162318 (Homer3)

Protein Structure

UniProt Annotation

Function

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Postsynaptic density of neuronal cells. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in the cerebellum, hippocampus, lung and thymus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0019904	protein domain specific binding

Biological Process

GO:0007216

G-protein coupled glutamate receptor signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0014069	postsynaptic density
GO:0030054	cell junction
GO:0045178	basal part of cell
GO:0045211	postsynaptic membrane