Version 5.4
Mus musculus Gene: Usp28
Summary
InnateDB Gene IDBG-162407.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Usp28
Gene Name ubiquitin specific peptidase 28
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000032267
Encoded Proteins
IDBP-162409
ubiquitin specific peptidase 28
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000048028:
The ubiquitin-dependent protein degradation pathway is essential for proteolysis of intracellular proteins and peptides. Enzymes that remove ubiquitin from ubiquitin-conjugated peptides, like USP28, affect the fate and degradation of intracellular proteins and are essential for maintenance of cell-free ubiquitin pools (Valero et al., 2001).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:48985385-49042517
Strand Forward strand
Band A5.3
Transcripts
ENSMUST00000047349 ENSMUSP00000047467
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 42 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0036459 ubiquitinyl hydrolase activity
Biological Process
GO:0000077 DNA damage checkpoint
GO:0006281 DNA repair
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006974 cellular response to DNA damage stimulus
GO:0008283 cell proliferation
GO:0010212 response to ionizing radiation
GO:0016579 protein deubiquitination
GO:0034644 cellular response to UV
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000048028
View Gene Order
ENSBTAG00000002323
Not yet available
Cross-References
SwissProt Q5I043
TrEMBL Q3TLH2
UniProt Splice Variant
Entrez Gene 235323
UniGene Mm.21630
RefSeq NM_175482 XM_006510264
OMIM
CCDS CCDS40613
HPRD
IMGT
MGI ID MGI:2442293
MGI Symbol Usp28
EMBL AK052442 AK129380 AK166511 BC066033 BC088733
GenPept AAH66033 AAH88733 BAC34993 BAC98190 BAE38820
RNA Seq Atlas 235323

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca