Version 5.4
Mus musculus Gene: Cd200r1
Summary
InnateDB Gene IDBG-162436.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd200r1
Gene Name CD200 receptor 1
Synonyms CD200R; Mox2r; OX2R
Species Mus musculus
Ensembl Gene ENSMUSG00000022667
Encoded Proteins
IDBP-162438
CD200 receptor 1
IDBP-706308
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25654642
Cd200-Cd200r1 pathway is an important regulator of antiviral immunity during cytomegalovirus infection that is exploited by murine cytomegalovirus to establish chronicity within mucosal tissue.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163606:
This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:44765736-44794978
Strand Forward strand
Band B4
Transcripts
ENSMUST00000057488 ENSMUSP00000053822
ENSMUST00000134625 ENSMUSP00000138076
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000163606
View Gene Order
ENSBTAG00000001235
Not yet available
Pathways
NETPATH
REACTOME
REACT_202937
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_230745
Immune System pathway
REACT_229531
Adaptive Immune System pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11152
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_213138
Immune System pathway
REACT_214469
Adaptive Immune System pathway
REACT_215390
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9ES57
TrEMBL
UniProt Splice Variant
Entrez Gene 57781
UniGene Mm.473608
RefSeq NM_021325
OMIM
CCDS CCDS28189
HPRD
IMGT
MGI ID MGI:1889024
MGI Symbol Cd200r1
EMBL AF231393 BC052682
GenPept AAF98556 AAH52682
RNA Seq Atlas 57781

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca