Version 5.4
Mus musculus Protein: Cd200r1
Summary
InnateDB Protein IDBP-162438.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd200r1
Protein Name CD200 receptor 1
Synonyms CD200R; Mox2r; OX2R;
Species Mus musculus
Ensembl Protein ENSMUSP00000053822
InnateDB Gene IDBG-162436 (Cd200r1)
Protein Structure
UniProt Annotation
Function Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. {ECO:0000269PubMed:12960329, ECO:0000269PubMed:15187158}.
Subcellular Localization Cell membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity Expressed in granulocytes, monocytes, most T- cells and a subset of NK, NKT and B-cells (at protein level). Expressed in the spleen, lung, liver, testis, bone marrow, lymph nodes, spinal cord, kidney, uterus and small intestine. Expressed in mast and dendritic cells. Expressed in the lung of N. brasiliensis-infected mice. {ECO:0000269PubMed:12960329, ECO:0000269PubMed:15187158, ECO:0000269PubMed:15274657, ECO:0000269PubMed:15471863}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex
Protein Structure and Domains
PDB ID MGI:1889024
InterPro IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
IPR013162 CD80-like, immunoglobulin C2-set
PFAM PF07686
PF08205
PRINTS
PIRSF
SMART SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9ES57
PhosphoSite PhosphoSite-Q9ES57
TrEMBL
UniProt Splice Variant
Entrez Gene 57781
UniGene Mm.473608
RefSeq NP_067300
MGI ID 4BFI
MGI Symbol Cd200r1
OMIM
CCDS CCDS28189
HPRD
IMGT
EMBL AF231393 BC052682
GenPept AAF98556 AAH52682

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca