InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MYH11

Summary

InnateDB Gene

IDBG-16251.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYH11

Gene Name

myosin, heavy chain 11, smooth muscle

Synonyms

AAT4; FAA4; SMHC; SMMHC

Species

Homo sapiens

Ensembl Gene

ENSG00000133392

Encoded Proteins

IDBP-16255

myosin, heavy chain 11, smooth muscle

IDBP-237694

myosin, heavy chain 11, smooth muscle

IDBP-370229

myosin, heavy chain 11, smooth muscle

IDBP-753800

IDBP-806967

myosin, heavy chain 11, smooth muscle

IDBP-806969

myosin, heavy chain 11, smooth muscle

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3\' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:15703135-15857033

Strand

Reverse strand

Band

p13.11

Transcripts

ENST00000300036	ENSP00000300036
ENST00000396324	ENSP00000379616
ENST00000452625	ENSP00000407821
ENST00000576164
ENST00000570785
ENST00000571505
ENST00000571910
ENST00000574119
ENST00000573908
ENST00000571275
ENST00000576790	ENSP00000458731
ENST00000611087	ENSP00000483524
ENST00000616439	ENSP00000484924

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003774	motor activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0008307	structural constituent of muscle
GO:0051015	actin filament binding

Biological Process

GO:0006936	muscle contraction
GO:0006939	smooth muscle contraction
GO:0007411	axon guidance
GO:0008152	metabolic process
GO:0016192	vesicle-mediated transport
GO:0030241	skeletal muscle myosin thick filament assembly
GO:0048251	elastic fiber assembly
GO:0048739	cardiac muscle fiber development

Cellular Component

GO:0001725	stress fiber
GO:0005829	cytosol
GO:0005859	muscle myosin complex
GO:0016020	membrane
GO:0016459	myosin complex
GO:0030485	smooth muscle contractile fiber
GO:0032982	myosin filament
GO:0042470	melanosome