Version 5.4
Mus musculus Gene: Sun2
Summary
InnateDB Gene IDBG-162524.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sun2
Gene Name Sad1 and UNC84 domain containing 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000042524
Encoded Proteins
IDBP-162526
Sad1 and UNC84 domain containing 2
IDBP-162528
Sad1 and UNC84 domain containing 2
IDBP-162530
Sad1 and UNC84 domain containing 2
IDBP-536459
Sad1 and UNC84 domain containing 2
IDBP-542624
Sad1 and UNC84 domain containing 2
IDBP-542348
Sad1 and UNC84 domain containing 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100242:
SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).[supplied by OMIM, Nov 2010]
SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a \'bridge\' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:79724070-79742536
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000089311 ENSMUSP00000086724
ENSMUST00000046259 ENSMUSP00000047864
ENSMUST00000100439 ENSMUSP00000098006
ENSMUST00000162392
ENSMUST00000159762
ENSMUST00000162064
ENSMUST00000159660 ENSMUSP00000124504
ENSMUST00000162499 ENSMUSP00000124515
ENSMUST00000160355 ENSMUSP00000124495
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005521 lamin binding
GO:0042802 identical protein binding
Biological Process
GO:0006998 nuclear envelope organization
GO:0030335 positive regulation of cell migration
GO:0031022 nuclear migration along microfilament
GO:0051642 centrosome localization
GO:0090286 cytoskeletal anchoring at nuclear membrane
GO:0090292 nuclear matrix anchoring at nuclear membrane
Cellular Component
GO:0000784 nuclear chromosome, telomeric region
GO:0000794 condensed nuclear chromosome
GO:0005635 nuclear envelope
GO:0005637 nuclear inner membrane
GO:0010008 endosome membrane
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
GO:0034993 SUN-KASH complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000100242
View Gene Order
ENSBTAG00000003693
Not yet available
Pathways
NETPATH
REACTOME
REACT_75800
Meiotic Synapsis pathway
REACT_200794
Mus musculus biological processes pathway
REACT_198626
Meiotic synapsis pathway
REACT_188804
Cell Cycle pathway
REACT_198624
Meiosis pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75792
Meiotic synapsis pathway
REACT_115566
Cell Cycle pathway
REACT_111183
Meiosis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q8BJS4
TrEMBL E0CY32 E0CY39
UniProt Splice Variant
Entrez Gene 223697
UniGene Mm.202715 Mm.488734 Mm.489119
RefSeq NM_001205346 NM_001205345 NM_194342 XM_006520811
OMIM
CCDS CCDS56992 CCDS27649 CCDS56993
HPRD
IMGT
MGI ID MGI:2443011
MGI Symbol Sun2
EMBL AC118227 AK080116 AK128958 AK156246 AK171058 AY682987 CH466550
GenPept AAT90499 BAC37829 BAC87662 BAE33640 BAE42217 EDL04635
RNA Seq Atlas 223697

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca