InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: UNC84B

Summary

InnateDB Gene

IDBG-641683.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UNC84B

Gene Name

SUN domain-containing protein 2

Synonyms

UNC84B

Species

Bos taurus

Ensembl Gene

ENSBTAG00000003693

Encoded Proteins

IDBP-694070

SUN domain-containing protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100242:
SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).[supplied by OMIM, Nov 2010]
SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a \'bridge\' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).[supplied by OMIM, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:110872317-110885520

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000004813

ENSBTAP00000004813

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005521	lamin binding
GO:0042802	identical protein binding

Biological Process

GO:0006998	nuclear envelope organization
GO:0030335	positive regulation of cell migration
GO:0031022	nuclear migration along microfilament
GO:0051642	centrosome localization
GO:0090286	cytoskeletal anchoring at nuclear membrane
GO:0090292	nuclear matrix anchoring at nuclear membrane

Cellular Component

GO:0000784	nuclear chromosome, telomeric region
GO:0000794	condensed nuclear chromosome
GO:0005635	nuclear envelope
GO:0005637	nuclear inner membrane
GO:0031965	nuclear membrane
GO:0034993	SUN-KASH complex