InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fdps

Summary

InnateDB Gene

IDBG-162570.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fdps

Gene Name

farnesyl diphosphate synthetase

Synonyms

6030492I17Rik; AI256750; Fdpsl1; mKIAA1293

Species

Mus musculus

Ensembl Gene

ENSMUSG00000059743

Encoded Proteins

IDBP-162572

farnesyl diphosphate synthetase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160752:
This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:89093592-89101967

Strand

Reverse strand

Band

Transcripts

ENSMUST00000081848

ENSMUSP00000080531

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004161	dimethylallyltranstransferase activity
GO:0004337	geranyltranstransferase activity
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006695	cholesterol biosynthetic process
GO:0008299	isoprenoid biosynthetic process
GO:0033384	geranyl diphosphate biosynthetic process
GO:0045337	farnesyl diphosphate biosynthetic process