InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fdps

Summary

InnateDB Protein

IDBP-162572.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fdps

Protein Name

farnesyl diphosphate synthetase

Synonyms

6030492I17Rik; AI256750; Fdpsl1; mKIAA1293;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000080531

InnateDB Gene

IDBG-162570 (Fdps)

Protein Structure

UniProt Annotation

Function

Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004161	dimethylallyltranstransferase activity
GO:0004337	geranyltranstransferase activity
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006695	cholesterol biosynthetic process
GO:0008299	isoprenoid biosynthetic process
GO:0033384	geranyl diphosphate biosynthetic process
GO:0045337	farnesyl diphosphate biosynthetic process