Version 5.4
Mus musculus Gene: Hcn3
Summary
InnateDB Gene IDBG-162768.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hcn3
Gene Name hyperpolarization-activated, cyclic nucleotide-gated K+ 3
Synonyms BCNG-4; Bcng4; Hac3; Hcn4
Species Mus musculus
Ensembl Gene ENSMUSG00000028051
Encoded Proteins
IDBP-162770
hyperpolarization-activated, cyclic nucleotide-gated K+ 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143630:
This gene encodes a multi-pass membrane protein that functions as a voltage gated cation channel. The encoded protein is a member of a family of closely related cyclic adenosine monophosphate-binding channel proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:89146074-89160196
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000029686 ENSMUSP00000029686
ENSMUST00000132156
ENSMUST00000127654
ENSMUST00000133368
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005272 sodium channel activity
GO:0005515 protein binding
GO:0030552 cAMP binding
Biological Process
GO:0006811 ion transport
GO:0034765 regulation of ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000143630
View Gene Order
ENSBTAG00000017055
Not yet available
Pathways
NETPATH
REACTOME
REACT_202800
Potassium Channels pathway
REACT_259290
Neuronal System pathway
REACT_199079
HCN channels pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_13685
Neuronal System pathway
REACT_75862
HCN channels pathway
REACT_75908
Potassium Channels pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt O88705
TrEMBL B2RRB5
UniProt Splice Variant
Entrez Gene 15168
UniGene Mm.389461 Mm.489362
RefSeq NM_008227
OMIM
CCDS CCDS17490
HPRD
IMGT
MGI ID MGI:1298211
MGI Symbol Hcn3
EMBL AJ225124 AK032225 BC039156 BC138319 BC138321 CH466547
GenPept AAH39156 AAI38320 AAI38322 BAC27769 CAA12408 EDL15235
RNA Seq Atlas 15168

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca