InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hcn3

Summary

InnateDB Protein

IDBP-162770.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hcn3

Protein Name

hyperpolarization-activated, cyclic nucleotide-gated K+ 3

Synonyms

BCNG-4; Bcng4; Hac3; Hcn4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029686

InnateDB Gene

IDBG-162768 (Hcn3)

Protein Structure

UniProt Annotation

Function

Hyperpolarization-activated potassium channel. May also facilitate the permeation of sodium ions. {ECO:0000269PubMed:15923185}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:15923185}; Multi-pass membrane protein {ECO:0000269PubMed:15923185}.

Disease Associations

Tissue Specificity

Detected in hypothalamus, amygdala, olfactory bulb, hippocampus and retina (at protein level). Highly expressed in brain and heart, in particular in ventricle, atrium and in sinoatrial node (SAN). Detected at low levels in skeletal muscle and lung. {ECO:0000269PubMed:15923185, ECO:0000269PubMed:9630217}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005248	voltage-gated sodium channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005272	sodium channel activity
GO:0005515	protein binding
GO:0030552	cAMP binding

Biological Process

GO:0006811	ion transport
GO:0034765	regulation of ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0042391	regulation of membrane potential
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1298211

InterPro

IPR000595 Cyclic nucleotide-binding domain
IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG
IPR005821 Ion transport domain
IPR013621 Ion transport N-terminal
IPR018490 Cyclic nucleotide-binding-like

PFAM

PF00027
PF00520
PF08412

PRINTS

PR01463

PIRSF

SMART

SM00100

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt