InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Zfp36

Summary

InnateDB Gene

IDBG-163345.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zfp36

Gene Name

zinc finger protein 36

Synonyms

Gos24; Nup475; Tis11; TIS11D; TISII; Ttp; Zfp-36

Species

Mus musculus

Ensembl Gene

ENSMUSG00000044786

Encoded Proteins

IDBP-163347

zinc finger protein 36

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 26019272

Dusp1 modulates the phosphorylation status of mRNA-destabilizing protein Zfp36 to regulate macrophage immune response to lipopolysaccharide.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128016:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:28376784-28379255

Strand

Reverse strand

Band

Transcripts

ENSMUST00000051241

ENSMUSP00000057815

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0017091	AU-rich element binding
GO:0019901	protein kinase binding
GO:0019957	C-C chemokine binding
GO:0035925	mRNA 3'-UTR AU-rich region binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding
GO:0071889	14-3-3 protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006402	mRNA catabolic process
GO:0032680	regulation of tumor necrosis factor production
GO:0035278	negative regulation of translation involved in gene silencing by miRNA
GO:0035556	intracellular signal transduction
GO:0042594	response to starvation
GO:0043488	regulation of mRNA stability
GO:0045087	innate immune response (InnateDB)
GO:0045638	negative regulation of myeloid cell differentiation
GO:0050728	negative regulation of inflammatory response
GO:0050779	RNA destabilization
GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0070935	3'-UTR-mediated mRNA stabilization
GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0010494	cytoplasmic stress granule

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000128016

View Gene Order

ENSBTAG00000008573

Not yet available

Pathways

NETPATH

REACTOME

REACT_198687

Regulation of mRNA stability by proteins that bind AU-rich elements pathway

REACT_198689

Tristetraprolin (TTP) destabilizes mRNA pathway

REACT_233572

Gene Expression pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_25064

Tristetraprolin (TTP) destabilizes mRNA pathway

REACT_24994

Regulation of mRNA stability by proteins that bind AU-rich elements pathway

REACT_71

Gene Expression pathway

KEGG

INOH

PID NCI

erbb1_downstream_pathway

ErbB1 downstream signaling

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.389856 Mm.398966

RefSeq

NM_011756

OMIM

CCDS

CCDS21041

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas