InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zfp36

Summary

InnateDB Protein

IDBP-163347.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zfp36

Protein Name

zinc finger protein 36

Synonyms

Gos24; Nup475; Tis11; TIS11D; TISII; Ttp; Zfp-36;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000057815

InnateDB Gene

IDBG-163345 (Zfp36)

Protein Structure

UniProt Annotation

Function

mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1. Plays a key role in the post- transcriptional regulation of tumor necrosis factor (TNF). {ECO:0000269PubMed:14688255, ECO:0000269PubMed:21278420}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11796723}. Cytoplasm {ECO:0000269PubMed:11796723}. Note=Localizes to stress granules upon energy starvation. phosphorylation by MAPKAPK2 promotes exclusion from stress granules (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Especially abundant in intestine, thymus and regenerating liver, and in macrophage cell line stimulated by gamma-interferon.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0017091	AU-rich element binding
GO:0019901	protein kinase binding
GO:0019957	C-C chemokine binding
GO:0035925	mRNA 3'-UTR AU-rich region binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding
GO:0071889	14-3-3 protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006402	mRNA catabolic process
GO:0032680	regulation of tumor necrosis factor production
GO:0035278	negative regulation of translation involved in gene silencing by miRNA
GO:0035556	intracellular signal transduction
GO:0042594	response to starvation
GO:0043488	regulation of mRNA stability
GO:0045087	innate immune response (InnateDB)
GO:0045638	negative regulation of myeloid cell differentiation
GO:0050728	negative regulation of inflammatory response
GO:0050779	RNA destabilization
GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0070935	3'-UTR-mediated mRNA stabilization
GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay