Version 5.4
Mus musculus Gene: Tab1
Summary
InnateDB Gene IDBG-163423.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tab1
Gene Name TGF-beta activated kinase 1/MAP3K7 binding protein 1
Synonyms 2310012M03Rik; b2b449Clo; Map3k7ip1
Species Mus musculus
Ensembl Gene ENSMUSG00000022414
Encoded Proteins
IDBP-163425
TGF-beta activated kinase 1/MAP3K7 binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 15590691
[Homo sapiens] MAP3K7IP1 induces MAP3K7 autophosphorylation/activation and inhibits MAP3K7 interaction with the IKK signalosome.
PMID 8638164
[Homo sapiens] MAP3K7IP1 functions as an activator of the MAP3K7 (TAK1) in TGF-beta signal transduction.
PMID 14592977
[Homo sapiens] MAP3K&IP1 participates in a SAPK2a/p38alpha-mediated feedback control of MAP3K7, which not only limits the activation of SAPK2a/p38alpha but synchronizes its activity with other signalling pathways that lie downstream of MAP3K7 (JNK and IKK).
PMID 16407200
[Homo sapiens] MAP3K7IP1 modulates intracellular localization of MAPK14 (p38) and downstream signalling.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100324:
The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:80133154-80161701
Strand Forward strand
Band E1
Transcripts
ENSMUST00000023050 ENSMUSP00000023050
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 97 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 97 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0019209 kinase activator activity
GO:0032403 protein complex binding
GO:0048273 mitogen-activated protein kinase p38 binding
Biological Process
GO:0000185 activation of MAPKKK activity
GO:0001701 in utero embryonic development
GO:0003007 heart morphogenesis
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0008152 metabolic process
GO:0030324 lung development
GO:0043406 positive regulation of MAP kinase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000100324
View Gene Order
ENSBTAG00000019828
Not yet available
Pathways
NETPATH
REACTOME
REACT_263316
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_229712
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_263004
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_239142
Innate Immune System pathway
REACT_204812
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 pathway
REACT_245896
MyD88 cascade initiated on plasma membrane pathway
REACT_205561
FCERI mediated NF-kB activation pathway
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_198690
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation pathway
REACT_255939
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_198539
TRAF6 mediated induction of TAK1 complex pathway
REACT_198536
IRAK2 mediated activation of TAK1 complex pathway
REACT_262171
MAP kinase activation in TLR cascade pathway
REACT_230745
Immune System pathway
REACT_260773
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_254406
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_237946
activated TAK1 mediates p38 MAPK activation pathway
REACT_249409
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_188204
Fc epsilon receptor (FCERI) signaling pathway
REACT_251547
Toll-Like Receptors Cascades pathway
REACT_261687
Signaling by Interleukins pathway
REACT_211125
NOD1/2 Signaling Pathway pathway
REACT_256727
MyD88 dependent cascade initiated on endosome pathway
REACT_206758
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
REACT_262462
Activated TLR4 signalling pathway
REACT_224208
Interleukin-1 signaling pathway
REACT_241786
MyD88-independent cascade pathway
REACT_242921
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_230045
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_238546
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_219800
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
REACT_261340
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_246719
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
mmu04620
Toll-like receptor signaling pathway pathway
mmu04010
MAPK signaling pathway pathway
mmu04621
NOD-like receptor signaling pathway pathway
mmu05140
Leishmaniasis pathway
mmu04380
Osteoclast differentiation pathway
mmu05145
Toxoplasmosis pathway
INOH
INOH website
IL-1 signaling pathway pathway
INOH website
Toll-like receptor signaling pathway pathway
INOH website
BMP2 signaling pathway
INOH website
TGF-beta signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
NetPath_9
TNFalpha pathway
NetPath_13
IL1 pathway
NetPath_21
RANKL pathway
REACTOME
REACT_21368
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 pathway
REACT_21399
activated TAK1 mediates p38 MAPK activation pathway
REACT_25351
TRAF6 mediated induction of TAK1 complex pathway
REACT_21281
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_25380
IRAK2 mediated activation of TAK1 complex pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_25018
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation pathway
REACT_25024
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_25222
MyD88 dependent cascade initiated on endosome pathway
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_27215
MyD88 cascade initiated on plasma membrane pathway
REACT_9027
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_9061
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_75776
NOD1/2 Signaling Pathway pathway
REACT_22442
Interleukin-1 signaling pathway
REACT_163994
FCERI mediated NF-kB activation pathway
REACT_9020
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_6802
Innate Immune System pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_21308
MAP kinase activation in TLR cascade pathway
REACT_75913
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
REACT_6900
Immune System pathway
REACT_22232
Signaling by Interleukins pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
KEGG
hsa04010
MAPK signaling pathway pathway
hsa04620
Toll-like receptor signaling pathway pathway
hsa04621
NOD-like receptor signaling pathway pathway
hsa05140
Leishmaniasis pathway
hsa04380
Osteoclast differentiation pathway
hsa05145
Toxoplasmosis pathway
INOH
INOH website
IL-1 signaling pathway pathway
INOH website
Toll-like receptor signaling pathway pathway
INOH website
TGF-beta signaling pathway
INOH website
BMP2 signaling pathway
PID NCI
ps1pathway
Presenilin action in Notch and Wnt signaling
il1pathway
IL1-mediated signaling events
p38alphabetapathway
Regulation of p38-alpha and p38-beta
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.288245
RefSeq NM_025609 XM_006521259
OMIM
CCDS CCDS27659
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca