InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tab1

Summary

InnateDB Protein

IDBP-163425.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tab1

Protein Name

TGF-beta activated kinase 1/MAP3K7 binding protein 1

Synonyms

2310012M03Rik; b2b449Clo; Map3k7ip1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023050

InnateDB Gene

IDBG-163423 (Tab1)

Protein Structure

UniProt Annotation

Function

May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 97 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	97 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0019209	kinase activator activity
GO:0032403	protein complex binding
GO:0048273	mitogen-activated protein kinase p38 binding

Biological Process

GO:0000185	activation of MAPKKK activity
GO:0001701	in utero embryonic development
GO:0003007	heart morphogenesis
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0008152	metabolic process
GO:0030324	lung development
GO:0043406	positive regulation of MAP kinase activity