Version 5.4
Mus musculus Gene: Nlgn3
Summary
InnateDB Gene IDBG-163514.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nlgn3
Gene Name neuroligin 3
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000031302
Encoded Proteins
IDBP-163520
neuroligin 3
IDBP-400704
neuroligin 3
IDBP-532283
neuroligin 3
IDBP-539412
neuroligin 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196338:
This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:101299168-101325963
Strand Forward strand
Band D
Transcripts
ENSMUST00000065858 ENSMUSP00000066304
ENSMUST00000118111 ENSMUSP00000113863
ENSMUST00000130555 ENSMUSP00000122213
ENSMUST00000151528 ENSMUSP00000123283
ENSMUST00000147443
ENSMUST00000144860
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0042043 neurexin family protein binding
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0002087 regulation of respiratory gaseous exchange by neurological system process
GO:0006898 receptor-mediated endocytosis
GO:0007155 cell adhesion
GO:0007158 neuron cell-cell adhesion
GO:0007416 synapse assembly
GO:0007612 learning
GO:0008152 metabolic process
GO:0008542 visual learning
GO:0030534 adult behavior
GO:0035176 social behavior
GO:0048675 axon extension
GO:0048709 oligodendrocyte differentiation
GO:0050804 regulation of synaptic transmission
GO:0050808 synapse organization
GO:0051965 positive regulation of synapse assembly
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0060024 rhythmic synaptic transmission
GO:0060079 regulation of excitatory postsynaptic membrane potential
GO:0060080 regulation of inhibitory postsynaptic membrane potential
GO:0061001 regulation of dendritic spine morphogenesis
GO:0071625 vocalization behavior
GO:0097104 postsynaptic membrane assembly
GO:0097105 presynaptic membrane assembly
GO:1900271 regulation of long-term synaptic potentiation
GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
GO:2000331 regulation of terminal button organization
GO:2000463 positive regulation of excitatory postsynaptic membrane potential
GO:2000969 positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
Cellular Component
GO:0005737 cytoplasm
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0030054 cell junction
GO:0030139 endocytic vesicle
GO:0045202 synapse
GO:0060076 excitatory synapse
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000196338
View Gene Order
ENSBTAG00000007708
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04514
Cell adhesion molecules (CAMs) pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.400081 Mm.407201 Mm.475053 Mm.483077 Mm.487713 Mm.490139
RefSeq NM_172932
OMIM
CCDS CCDS30313
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca