InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sdhd

Summary

InnateDB Gene

IDBG-163554.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sdhd

Gene Name

succinate dehydrogenase complex, subunit D, integral membrane protein

Synonyms

3110001M13Rik; AVLL5809; C78570; PRO19626

Species

Mus musculus

Ensembl Gene

ENSMUSG00000000171

Encoded Proteins

IDBP-163556

succinate dehydrogenase complex, subunit D, integral membrane protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204370:
This gene encodes a member of complex II of the respiratory chain, which is responsible for the oxidation of succinate. The encoded protein is one of two integral membrane proteins anchoring the complex to the matrix side of the mitochondrial inner membrane. Mutations in this gene are associated with the formation of tumors, including hereditary paraganglioma. Transmission of disease occurs almost exclusively through the paternal allele, suggesting that this locus may be maternally imprinted. There are pseudogenes for this gene on chromosomes 1, 2, 3, 7, and 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:50596338-50603849

Strand

Reverse strand

Band

A5.3

Transcripts

ENSMUST00000000175

ENSMUSP00000000175

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0020037	heme binding
GO:0046872	metal ion binding
GO:0048039	ubiquinone binding

Biological Process

GO:0006099

tricarboxylic acid cycle

Cellular Component

GO:0005739	mitochondrion
GO:0005740	mitochondrial envelope
GO:0005743	mitochondrial inner membrane
GO:0005749	mitochondrial respiratory chain complex II
GO:0016021	integral component of membrane