InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Acadl

Summary

InnateDB Gene

IDBG-163605.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Acadl

Gene Name

acyl-Coenzyme A dehydrogenase, long-chain

Synonyms

AA960361; AU018452; C79855; LCAD

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026003

Encoded Proteins

IDBP-163607

acyl-Coenzyme A dehydrogenase, long-chain

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a homotetrameric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum length between C12- and C16-acylCoA. In mice, deficiency of this gene can cause sudden death, cardiomyopathy as well as fasting and cold intolerance. [provided by RefSeq, Nov 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:66830839-66863277

Strand

Reverse strand

Band

Transcripts

ENSMUST00000027153	ENSMUSP00000027153
ENSMUST00000139208

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000062	fatty-acyl-CoA binding
GO:0003995	acyl-CoA dehydrogenase activity
GO:0004466	long-chain-acyl-CoA dehydrogenase activity
GO:0016401	palmitoyl-CoA oxidase activity
GO:0016491	oxidoreductase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0001659	temperature homeostasis
GO:0008152	metabolic process
GO:0019254	carnitine metabolic process, CoA-linked
GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO:0042413	carnitine catabolic process
GO:0042758	long-chain fatty acid catabolic process
GO:0044242	cellular lipid catabolic process
GO:0045717	negative regulation of fatty acid biosynthetic process
GO:0046322	negative regulation of fatty acid oxidation
GO:0051289	protein homotetramerization
GO:0055114	oxidation-reduction process
GO:0090181	regulation of cholesterol metabolic process