Mus musculus Gene: Dpm3
Summary
InnateDB Gene IDBG-163656.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dpm3
Gene Name dolichyl-phosphate mannosyltransferase polypeptide 3
Synonyms 1110001H19Rik; AV117483
Species Mus musculus
Ensembl Gene ENSMUSG00000042737
Encoded Proteins
dolichyl-phosphate mannosyltransferase polypeptide 3
dolichyl-phosphate mannosyltransferase polypeptide 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000179085:
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a subunit of dolichyl-phosphate mannosyltransferase and acts as a stabilizer subunit of the dolichyl-phosphate mannosyltransferase complex. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:89259358-89267079
Strand Forward strand
Band F1
Transcripts
ENSMUST00000040824 ENSMUSP00000040860
ENSMUST00000107462 ENSMUSP00000103086
ENSMUST00000137975
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity
GO:0005515 protein binding
Biological Process
GO:0006486 protein glycosylation
GO:0006506 GPI anchor biosynthetic process
GO:0031647 regulation of protein stability
GO:0097502 mannosylation
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0016020 membrane
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0033185 dolichol-phosphate-mannose synthase complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Synthesis of substrates in N-glycan biosythesis pathway
Post-translational modification: synthesis of GPI-anchored proteins pathway
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
Metabolism of proteins pathway
Post-translational protein modification pathway
Synthesis of dolichyl-phosphate mannose pathway
Asparagine N-linked glycosylation pathway
KEGG
N-Glycan biosynthesis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Synthesis of dolichyl-phosphate mannose pathway
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
Asparagine N-linked glycosylation pathway
Post-translational modification: synthesis of GPI-anchored proteins pathway
Post-translational protein modification pathway
Synthesis of substrates in N-glycan biosythesis pathway
Metabolism of proteins pathway
Post-translational modification: synthesis of GPI-anchored proteins pathway
Asparagine N-linked glycosylation pathway
Metabolism of proteins pathway
Post-translational protein modification pathway
Synthesis of dolichyl-phosphate mannose pathway
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
Synthesis of substrates in N-glycan biosythesis pathway
KEGG
N-Glycan biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt Q9D1Q4
TrEMBL
UniProt Splice Variant
Entrez Gene 68563
UniGene
RefSeq XM_006501982 XM_006501983 NM_026767
OMIM
CCDS CCDS38487
HPRD
IMGT
MGI ID MGI:1915813
MGI Symbol Dpm3
EMBL AK003223 BC037761
GenPept BAB22652
RNA Seq Atlas 68563