Version 5.4
Bos taurus Gene: DPM3
Summary
InnateDB Gene IDBG-632218.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DPM3
Gene Name Dolichol-phosphate mannosyltransferase subunit 3
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000003535
Encoded Proteins
IDBP-683819
Dolichol-phosphate mannosyltransferase subunit 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000179085:
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a subunit of dolichyl-phosphate mannosyltransferase and acts as a stabilizer subunit of the dolichyl-phosphate mannosyltransferase complex. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:15517158-15517733
Strand Forward strand
Band
Transcripts
ENSBTAT00000004597 ENSBTAP00000004597
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity
GO:0005515 protein binding
Biological Process
GO:0006486 protein glycosylation
GO:0006506 GPI anchor biosynthetic process
GO:0031647 regulation of protein stability
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0033185 dolichol-phosphate-mannose synthase complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000179085
View Gene Order
ENSMUSG00000042737
View Gene Order
Pathways
NETPATH
REACTOME
REACT_223512
Post-translational modification: synthesis of GPI-anchored proteins pathway
REACT_223866
Asparagine N-linked glycosylation pathway
REACT_213782
Metabolism of proteins pathway
REACT_214405
Post-translational protein modification pathway
REACT_209172
Synthesis of dolichyl-phosphate mannose pathway
REACT_220681
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
REACT_226954
Synthesis of substrates in N-glycan biosythesis pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_2032
Synthesis of dolichyl-phosphate mannose pathway
REACT_22433
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_1853
Post-translational modification: synthesis of GPI-anchored proteins pathway
REACT_22161
Post-translational protein modification pathway
REACT_22387
Synthesis of substrates in N-glycan biosythesis pathway
REACT_17015
Metabolism of proteins pathway
REACT_248642
Synthesis of substrates in N-glycan biosythesis pathway
REACT_244576
Post-translational modification: synthesis of GPI-anchored proteins pathway
REACT_262413
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
REACT_247926
Metabolism of proteins pathway
REACT_236283
Post-translational protein modification pathway
REACT_251842
Synthesis of dolichyl-phosphate mannose pathway
REACT_237472
Asparagine N-linked glycosylation pathway
KEGG
hsa00510
N-Glycan biosynthesis pathway
mmu00510
N-Glycan biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt Q3ZC71
TrEMBL
UniProt Splice Variant
Entrez Gene 509745
UniGene Bt.49459
RefSeq NM_001034360
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102881
GenPept AAI02882
RNA Seq Atlas 509745

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca