Mus musculus Gene: Pak4 | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-163840.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Pak4 | ||||||||||||||||||||||
Gene Name | p21 protein (Cdc42/Rac)-activated kinase 4 | ||||||||||||||||||||||
Synonyms | 5730488L07Rik; AW555722; mKIAA1142 | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000030602 | ||||||||||||||||||||||
Encoded Proteins |
p21 protein (Cdc42/Rac)-activated kinase 4
p21 protein (Cdc42/Rac)-activated kinase 4
|
||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130669:
PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
||||||||||||||||||||||
Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 7:28399549-28598185 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | B1 | ||||||||||||||||||||||
Transcripts |
|
||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
|
||||||||||||||||||||||
Gene Ontology | |||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||
Biological Process |
|
||||||||||||||||||||||
Cellular Component |
|
||||||||||||||||||||||
Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||||||||||||||||||
Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Signaling by Robo receptor pathway
Axon guidance pathway
Developmental Biology pathway
Activation of Rac pathway
|
||||||||||||||||||||||
KEGG |
Axon guidance pathway
Renal cell carcinoma pathway
ErbB signaling pathway pathway
T cell receptor signaling pathway pathway
Regulation of actin cytoskeleton pathway
Focal adhesion pathway
|
||||||||||||||||||||||
INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
|
||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Activation of Rac pathway
Signaling by Robo receptor pathway
Developmental Biology pathway
Axon guidance pathway
|
||||||||||||||||||||||
KEGG |
Regulation of actin cytoskeleton pathway
ErbB signaling pathway pathway
Renal cell carcinoma pathway
Axon guidance pathway
Focal adhesion pathway
T cell receptor signaling pathway pathway
|
||||||||||||||||||||||
INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
|
||||||||||||||||||||||
PID NCI |
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
FGF signaling pathway
CDC42 signaling events
|
||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q8BTW9 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 70584 | ||||||||||||||||||||||
UniGene | Mm.21876 | ||||||||||||||||||||||
RefSeq | NM_027470 NM_175021 XM_006540356 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS21049 CCDS21044 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | MGI:1917834 | ||||||||||||||||||||||
MGI Symbol | Pak4 | ||||||||||||||||||||||
EMBL | AK017713 AK088512 AK129298 AY217016 BC048238 | ||||||||||||||||||||||
GenPept | AAH48238 AAO61496 BAB30889 BAC40396 BAC98108 | ||||||||||||||||||||||
RNA Seq Atlas | 233033 70584 | ||||||||||||||||||||||