InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pak4

Summary

InnateDB Gene

IDBG-163840.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pak4

Gene Name

p21 protein (Cdc42/Rac)-activated kinase 4

Synonyms

5730488L07Rik; AW555722; mKIAA1142

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030602

Encoded Proteins

IDBP-163842

p21 protein (Cdc42/Rac)-activated kinase 4

IDBP-264868

p21 protein (Cdc42/Rac)-activated kinase 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130669:
PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:28399549-28598185

Strand

Reverse strand

Band

Transcripts

ENSMUST00000032823	ENSMUSP00000032823
ENSMUST00000108283	ENSMUSP00000103918
ENSMUST00000135923
ENSMUST00000150454

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007049	cell cycle
GO:0008150	biological_process
GO:0023014	signal transduction by phosphorylation
GO:0035556	intracellular signal transduction