Version 5.4
Homo sapiens Gene: PAK4
Summary
InnateDB Gene IDBG-49980.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PAK4
Gene Name p21 protein (Cdc42/Rac)-activated kinase 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000130669
Encoded Proteins
IDBP-49982
p21 protein (Cdc42/Rac)-activated kinase 4
IDBP-49984
p21 protein (Cdc42/Rac)-activated kinase 4
IDBP-49986
p21 protein (Cdc42/Rac)-activated kinase 4
IDBP-760050
IDBP-766093
IDBP-764942
IDBP-764975
IDBP-764372
IDBP-764148
IDBP-764961
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:39125770-39182816
Strand Forward strand
Band q13.2
Transcripts
ENST00000358301 ENSP00000351049
ENST00000360442 ENSP00000353625
ENST00000321944 ENSP00000326864
ENST00000602004 ENSP00000471318
ENST00000599657 ENSP00000473215
ENST00000600350
ENST00000599470 ENSP00000470284
ENST00000597766
ENST00000593690 ENSP00000469413
ENST00000599386 ENSP00000471157
ENST00000593480 ENSP00000472862
ENST00000597715 ENSP00000472061
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 36 [view]
Protein-Protein 33 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006928 cellular component movement
GO:0007010 cytoskeleton organization
GO:0007049 cell cycle
GO:0007165 signal transduction
GO:0008283 cell proliferation
GO:0016049 cell growth
GO:0016477 cell migration
GO:0023014 signal transduction by phosphorylation
Cellular Component
GO:0005794 Golgi apparatus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030602
View Gene Order
ENSBTAG00000013958
Not yet available
Pathways
NETPATH
REACTOME
REACT_19226
Activation of Rac pathway
REACT_19351
Signaling by Robo receptor pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04012
ErbB signaling pathway pathway
hsa05211
Renal cell carcinoma pathway
hsa04360
Axon guidance pathway
hsa04510
Focal adhesion pathway
hsa04660
T cell receptor signaling pathway pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
fgf_pathway
FGF signaling pathway
cdc42_pathway
CDC42 signaling events
Cross-References
SwissProt O96013
TrEMBL A0A024R0J1 B4DUG0 M0R2X4
UniProt Splice Variant
Entrez Gene 10298
UniGene Hs.20447
RefSeq XM_006722971 NM_001014831 NM_001014832 NM_001014834 NM_001014835 NM_005884 XM_006722972
HUGO HGNC:16059
OMIM 605451
CCDS CCDS12528 CCDS33019
HPRD 05675
IMGT
EMBL AB032968 AC011443 AF005046 AJ011855 AK074728 AK294586 AK300632 AL834236 BC002921 BC011368 BC025282 BC034511 CH471126
GenPept AAD01210 AAH02921 AAH11368 AAH25282 AAH34511 BAA86456 BAC11166 BAG57777 BAG62322 CAA09820 CAD38914 EAW56858 EAW56859 EAW56861 EAW56864 EAW56865 EAW56866
RNA Seq Atlas 10298

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca