InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Jund

Summary

InnateDB Gene

IDBG-163863.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Jund

Gene Name

Jun proto-oncogene related gene d

Synonyms

Jund1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000071076

Encoded Proteins

IDBP-163865

Jun proto-oncogene related gene d

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. It has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternate translation initiation site usage, including non-AUG codons, results in the production of different isoforms. [provided by RefSeq, Jul 2008]
The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:70697739-70700616

Strand

Forward strand

Band

B3.3

Transcripts

ENSMUST00000095267

ENSMUSP00000092901

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	12 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	45 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0016922	ligand-dependent nuclear receptor binding
GO:0019899	enzyme binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0002076	osteoblast development
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007568	aging
GO:0007623	circadian rhythm
GO:0009416	response to light stimulus
GO:0009612	response to mechanical stimulus
GO:0014070	response to organic cyclic compound
GO:0032496	response to lipopolysaccharide
GO:0043434	response to peptide hormone
GO:0045669	positive regulation of osteoblast differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0071277	cellular response to calcium ion

Cellular Component

GO:0005634	nucleus
GO:0043234	protein complex

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000130522

View Gene Order

Pathways

NETPATH

REACTOME

KEGG

mmu04010

MAPK signaling pathway pathway

mmu04380

Osteoclast differentiation pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_4

EGFR1 pathway

NetPath_7

TGF_beta_Receptor pathway

NetPath_114

Oncostatin_M pathway

REACTOME

KEGG

hsa04010

MAPK signaling pathway pathway

hsa04380

Osteoclast differentiation pathway

INOH

PID NCI

fra_pathway

Validated transcriptional targets of AP1 family members Fra1 and Fra2

atf2_pathway

ATF-2 transcription factor network

ap1_pathway

AP-1 transcription factor network

pdgfrbpathway

PDGFR-beta signaling pathway

Cross-References

SwissProt

P15066

TrEMBL

UniProt Splice Variant

Entrez Gene

16478

UniGene

Mm.455503 Mm.476682

RefSeq

NM_001286944 NM_010592

OMIM

CCDS

CCDS40375

HPRD

IMGT

MGI ID

MGI:96648

MGI Symbol

Jund

EMBL

BC010572 J04509 J05205 X15358

GenPept

AAA39344 AAA39345 AAH10572 CAA33418

RNA Seq Atlas

16478