InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pck2

Summary

InnateDB Gene

IDBG-163923.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pck2

Gene Name

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

Synonyms

1810010O14Rik; 9130022B02Rik; PEPCK-M

Species

Mus musculus

Ensembl Gene

ENSMUSG00000040618

Encoded Proteins

IDBP-163925

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100889:
This gene encodes a member of the phosphoenolpyruvate carboxykinase (GTP) family. The protein is a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of GTP. A cytosolic form encoded by a different gene has also been characterized and is the key enzyme of gluconeogenesis in the liver. The encoded protein may serve a similar function, although it is constitutively expressed and not modulated by hormones such as glucagon and insulin that regulate the cytosolic form. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
This gene encodes a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of guanosine triphosphate (GTP). A cytosolic form of this protein is encoded by a different gene and is the key enzyme of gluconeogenesis in the liver. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:55540266-55550017

Strand

Forward strand

Band

Transcripts

ENSMUST00000048781

ENSMUSP00000038555

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004611	phosphoenolpyruvate carboxykinase activity
GO:0004613	phosphoenolpyruvate carboxykinase (GTP) activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0017076	purine nucleotide binding
GO:0046872	metal ion binding

Biological Process

GO:0006090	pyruvate metabolic process
GO:0006094	gluconeogenesis
GO:0006107	oxaloacetate metabolic process
GO:0006116	NADH oxidation
GO:0032024	positive regulation of insulin secretion
GO:0051384	response to glucocorticoid
GO:0071333	cellular response to glucose stimulus