Version 5.4
Mus musculus Gene: Ubash3a
Summary
InnateDB Gene IDBG-163965.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ubash3a
Gene Name ubiquitin associated and SH3 domain containing, A
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000042345
Encoded Proteins
IDBP-163967
ubiquitin associated and SH3 domain containing, A
IDBP-538666
ubiquitin associated and SH3 domain containing, A
IDBP-625871
ubiquitin associated and SH3 domain containing, A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160185:
This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family members can negatively regulate T-cell signaling. This family member can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:31207873-31242202
Strand Forward strand
Band A3.3
Transcripts
ENSMUST00000048656 ENSMUSP00000045890
ENSMUST00000144772 ENSMUSP00000119279
ENSMUST00000151620
ENSMUST00000147686
ENSMUST00000173776 ENSMUSP00000134557
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005515 protein binding
Biological Process
GO:0001817 regulation of cytokine production
GO:0008152 metabolic process
GO:0050860 negative regulation of T cell receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000160185
View Gene Order
ENSBTAG00000023398
Not yet available
Cross-References
SwissProt
TrEMBL D6RCF9
UniProt Splice Variant
Entrez Gene 328795
UniGene Mm.387930
RefSeq NM_177823
OMIM
CCDS CCDS50054
HPRD
IMGT
MGI ID MGI:1926074
MGI Symbol Ubash3a
EMBL AC154652 AC167247 CU024900
GenPept
RNA Seq Atlas 328795

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca