InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ubash3a

Summary

InnateDB Protein

IDBP-163967.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ubash3a

Protein Name

ubiquitin associated and SH3 domain containing, A

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000045890

InnateDB Gene

IDBG-163965 (Ubash3a)

Protein Structure

UniProt Annotation

Function

Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain (By similarity). Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. {ECO:0000250, ECO:0000269PubMed:19196006}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding

Biological Process

GO:0001817	regulation of cytokine production
GO:0008152	metabolic process
GO:0050860	negative regulation of T cell receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:1926074

InterPro

IPR001452 SH3 domain
IPR009060 UBA-like
IPR013078 Histidine phosphatase superfamily, clade-1
IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
IPR029033 Histidine phosphatase superfamily

PFAM

PF00018
PF14604
PF00300

PRINTS

PR00452

PIRSF

SMART

SM00326
SM00855
SM00165

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt