InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Adsl

Summary

InnateDB Gene

IDBG-164155.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adsl

Gene Name

adenylosuccinate lyase

Synonyms

Adl; Asl

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022407

Encoded Proteins

IDBP-164157

adenylosuccinate lyase

IDBP-621637

adenylosuccinate lyase

IDBP-621639

adenylosuccinate lyase

IDBP-621640

adenylosuccinate lyase

IDBP-621641

adenylosuccinate lyase

IDBP-621642

adenylosuccinate lyase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein that is involved in adenosine monophosphate (AMP) biosynthesis and maintaining AMP levels in the muscle. The encoded enzyme catalyzes the release of fumarate during AMP biosynthesis by cleaving the substrates succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide (AICA) ribotide, and adenylosuccinate to give adenylate. In humans, this gene is associated with adenylosuccinate deficiency, a rare autosomal disorder resulting in a spectrum of neurological symptoms. A pseudogene associated with this gene is located on the X chromosome. [provided by RefSeq, Jan 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:80948490-80970947

Strand

Forward strand

Band

Transcripts

ENSMUST00000023043	ENSMUSP00000023043
ENSMUST00000166711	ENSMUSP00000129601
ENSMUST00000169238	ENSMUSP00000132423
ENSMUST00000164371
ENSMUST00000168756	ENSMUSP00000127593
ENSMUST00000164806	ENSMUSP00000131998
ENSMUST00000170354	ENSMUSP00000132524
ENSMUST00000163575

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004018	N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
GO:0070626	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity

Biological Process

GO:0001666	response to hypoxia
GO:0006163	purine nucleotide metabolic process
GO:0006167	AMP biosynthetic process
GO:0006189	'de novo' IMP biosynthetic process
GO:0007584	response to nutrient
GO:0008152	metabolic process
GO:0009060	aerobic respiration
GO:0009152	purine ribonucleotide biosynthetic process
GO:0009156	ribonucleoside monophosphate biosynthetic process
GO:0014850	response to muscle activity
GO:0042594	response to starvation
GO:0044208	'de novo' AMP biosynthetic process
GO:0051262	protein tetramerization