InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Adsl

Summary

InnateDB Protein

IDBP-164157.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adsl

Protein Name

adenylosuccinate lyase

Synonyms

Adl; Asl;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023043

InnateDB Gene

IDBG-164155 (Adsl)

Protein Structure

UniProt Annotation

Function

Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004018	N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
GO:0070626	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity

Biological Process

GO:0001666	response to hypoxia
GO:0006163	purine nucleotide metabolic process
GO:0006167	AMP biosynthetic process
GO:0006189	'de novo' IMP biosynthetic process
GO:0007584	response to nutrient
GO:0008152	metabolic process
GO:0009060	aerobic respiration
GO:0009152	purine ribonucleotide biosynthetic process
GO:0009156	ribonucleoside monophosphate biosynthetic process
GO:0014850	response to muscle activity
GO:0042594	response to starvation
GO:0044208	'de novo' AMP biosynthetic process
GO:0051262	protein tetramerization

Cellular Component

GO:0005739	mitochondrion
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:103202

InterPro

IPR000362 Fumarate lyase family
IPR004769 Adenylosuccinate lyase
IPR008948 L-Aspartase-like
IPR019468 Adenylosuccinate lyase C-terminal
IPR022761 Fumarate lyase, N-terminal

PFAM

PF10397
PF00206

PRINTS

PR00149

PIRSF

SMART

SM00998

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt