InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Il12rb1

Summary

InnateDB Gene

IDBG-164327.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il12rb1

Gene Name

interleukin 12 receptor, beta 1

Synonyms

CD212; IL-12R[b]

Species

Mus musculus

Ensembl Gene

ENSMUSG00000000791

Encoded Proteins

IDBP-164331

interleukin 12 receptor, beta 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000096996:
The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:70808449-70821424

Strand

Forward strand

Band

B3.3

Transcripts

ENSMUST00000000808

ENSMUSP00000000808

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	6 [view]
Protein-DNA	10 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005143	interleukin-12 receptor binding
GO:0005515	protein binding
GO:0016517	interleukin-12 receptor activity
GO:0019955	cytokine binding
GO:0042019	interleukin-23 binding
GO:0042020	interleukin-23 receptor activity

Biological Process

GO:0018108	peptidyl-tyrosine phosphorylation
GO:0032729	positive regulation of interferon-gamma production
GO:0035722	interleukin-12-mediated signaling pathway
GO:0038155	interleukin-23-mediated signaling pathway
GO:0042104	positive regulation of activated T cell proliferation
GO:0071346	cellular response to interferon-gamma