InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Il12rb1

Summary

InnateDB Protein

IDBP-164331.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il12rb1

Protein Name

interleukin 12 receptor, beta 1

Synonyms

CD212; IL-12R[b];

Species

Mus musculus

Ensembl Protein

ENSMUSP00000000808

InnateDB Gene

IDBG-164327 (Il12rb1)

Protein Structure

UniProt Annotation

Function

Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	6 [view]
Protein-DNA	10 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005143	interleukin-12 receptor binding
GO:0005515	protein binding
GO:0016517	interleukin-12 receptor activity
GO:0019955	cytokine binding
GO:0042019	interleukin-23 binding
GO:0042020	interleukin-23 receptor activity

Biological Process

GO:0018108	peptidyl-tyrosine phosphorylation
GO:0032729	positive regulation of interferon-gamma production
GO:0035722	interleukin-12-mediated signaling pathway
GO:0038155	interleukin-23-mediated signaling pathway
GO:0042104	positive regulation of activated T cell proliferation
GO:0071346	cellular response to interferon-gamma