Version 5.4
Mus musculus Gene: Fabp6
Summary
InnateDB Gene IDBG-164340.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fabp6
Gene Name fatty acid binding protein 6, ileal (gastrotropin)
Synonyms GT; I-15P; I-BABP; ILBP; ILBP3; Illbp
Species Mus musculus
Ensembl Gene ENSMUSG00000020405
Encoded Proteins
IDBP-164342
fatty acid binding protein 6, ileal (gastrotropin)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is part of the fatty acid binding protein family (FABP). FABPs are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands and participate in fatty acid uptake, transport, and metabolism. This protein functions within the ileum, the distal 25-30% of the small intestine, and plays a role in enterohepatic circulation of bile acids and cholesterol homeostasis. In humans, it has been reported that polymorphisms in FABP6 confer a protective effect in obese individuals from developing type 2 diabetes. In mice deficiency of this gene affects bile acid metabolism in a gender-specific manner and was reported to be required for efficient apical to basolateral transport of conjugated bile acids. [provided by RefSeq, Jan 2013]
The protein encoded by this gene is part of the fatty acid binding protein family (FABP). FABPs are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands and participate in fatty acid uptake, transport, and metabolism. This protein functions within the ileum, the distal 25-30%% of the small intestine, and plays a role in enterohepatic circulation of bile acids and cholesterol homeostasis. In humans, it has been reported that polymorphisms in FABP6 confer a protective effect in obese individuals from developing type 2 diabetes. In mice deficiency of this gene affects bile acid metabolism in a gender-specific manner and was reported to be required for efficient apical to basolateral transport of conjugated bile acids. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:43596049-43601540
Strand Reverse strand
Band B1.1
Transcripts
ENSMUST00000020672 ENSMUSP00000020672
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0008289 lipid binding
Biological Process
GO:0006810 transport
GO:0008206 bile acid metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005794 Golgi apparatus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000170231
View Gene Order
ENSBTAG00000010632
Not yet available
Pathways
NETPATH
REACTOME
REACT_239346
Recycling of bile acids and salts pathway
REACT_268398
Orphan transporters pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_229469
Bile acid and bile salt metabolism pathway
KEGG
mmu03320
PPAR signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11042
Recycling of bile acids and salts pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_11040
Bile acid and bile salt metabolism pathway
REACT_267716
Orphan transporters pathway
REACT_111217
Metabolism pathway
REACT_271057
Orphan transporters pathway
REACT_223874
Recycling of bile acids and salts pathway
REACT_223103
Transmembrane transport of small molecules pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_223789
Bile acid and bile salt metabolism pathway
REACT_219139
Metabolism pathway
KEGG
hsa03320
PPAR signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt P51162
TrEMBL
UniProt Splice Variant
Entrez Gene 16204
UniGene Mm.142716
RefSeq NM_008375
OMIM
CCDS CCDS24560
HPRD
IMGT
MGI ID MGI:96565
MGI Symbol Fabp6
EMBL AL670472 BC119289 BC120767 CH466575 U00938
GenPept AAC27352 AAI19290 AAI20768 CAI24826 EDL33855
RNA Seq Atlas 16204

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca