Version 5.4
Homo sapiens Gene: FABP6
Summary
InnateDB Gene IDBG-55997.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FABP6
Gene Name fatty acid binding protein 6, ileal
Synonyms I-15P; I-BABP; I-BALB; I-BAP; ILBP; ILBP3; ILLBP
Species Homo sapiens
Ensembl Gene ENSG00000170231
Encoded Proteins
IDBP-242525
fatty acid binding protein 6, ileal
IDBP-295181
fatty acid binding protein 6, ileal
IDBP-480054
fatty acid binding protein 6, ileal
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the ileal fatty acid binding protein. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP6 and FABP1 (the liver fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. Transcript variants generated by alternate transcription promoters and/or alternate splicing have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:160187367-160238735
Strand Forward strand
Band q33.3
Transcripts
ENST00000393980 ENSP00000377549
ENST00000402432 ENSP00000385433
ENST00000523955 ENSP00000428766
ENST00000521362
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0008289 lipid binding
Biological Process
GO:0006629 lipid metabolic process
GO:0008206 bile acid metabolic process
GO:0008285 negative regulation of cell proliferation
GO:0015721 bile acid and bile salt transport
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020405
View Gene Order
ENSBTAG00000010632
Not yet available
Pathways
NETPATH
REACTOME
REACT_11042
Recycling of bile acids and salts pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_11040
Bile acid and bile salt metabolism pathway
REACT_267716
Orphan transporters pathway
REACT_111217
Metabolism pathway
KEGG
hsa03320
PPAR signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL H0YB64
UniProt Splice Variant
Entrez Gene 2172
UniGene Hs.519719
RefSeq NM_001040442 NM_001130958 NM_001445 XM_006714828 XM_006714830
HUGO HGNC:3561
OMIM 600422
CCDS CCDS43393 CCDS4349
HPRD 02689
IMGT
EMBL AC008609 AC112191
GenPept
RNA Seq Atlas 2172

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca