Version 5.4
Mus musculus Gene: Sik1
Summary
InnateDB Gene IDBG-164811.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sik1
Gene Name salt inducible kinase 1
Synonyms Msk; Sik; Snf1lk
Species Mus musculus
Ensembl Gene ENSMUSG00000024042
Encoded Proteins
IDBP-164813
salt inducible kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000142178:
Gene Information
Type Protein coding
Genomic Location Chromosome 17:31844248-31855792
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000024839 ENSMUSP00000024839
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008140 cAMP response element binding protein binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
GO:0042826 histone deacetylase binding
GO:0071889 14-3-3 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002028 regulation of sodium ion transport
GO:0006468 protein phosphorylation
GO:0007049 cell cycle
GO:0007346 regulation of mitotic cell cycle
GO:0010830 regulation of myotube differentiation
GO:0010868 negative regulation of triglyceride biosynthetic process
GO:0032792 negative regulation of CREB transcription factor activity
GO:0035556 intracellular signal transduction
GO:0043276 anoikis
GO:0045595 regulation of cell differentiation
GO:0045721 negative regulation of gluconeogenesis
GO:0046777 protein autophosphorylation
GO:0055007 cardiac muscle cell differentiation
GO:2000210 positive regulation of anoikis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000142178
View Gene Order
ENSBTAG00000011437
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
KEGG
INOH
PID NCI
lkb1_pathway
LKB1 signaling events
Cross-References
SwissProt Q60670
TrEMBL Q571I6
UniProt Splice Variant
Entrez Gene 17691
UniGene Mm.290941 Mm.363958 Mm.416343
RefSeq NM_010831
OMIM
CCDS CCDS37552
HPRD
IMGT
MGI ID MGI:104754
MGI Symbol Sik1
EMBL AK141817 AK220203 U11494
GenPept AAA67926 BAD90128 BAE24842
RNA Seq Atlas 17691

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca