Version 5.4
Mus musculus Gene: Stim2
Summary
InnateDB Gene IDBG-164870.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Stim2
Gene Name stromal interaction molecule 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000039156
Encoded Proteins
IDBP-164872
stromal interaction molecule 2
IDBP-400964
stromal interaction molecule 2
IDBP-534641
stromal interaction molecule 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109689:
This gene is a member of the stromal interaction molecule (STIM) family and likely arose, along with related family member STIM1, from a common ancestral gene. The encoded protein functions to regulate calcium concentrations in the cytosol and endoplasmic reticulum, and is involved in the activation of plasma membrane Orai Ca(2+) entry channels. This gene initiates translation from a non-AUG (UUG) start site. A signal peptide is cleaved from the resulting protein. Multiple transcript variants result from alternative splicing. [provided by RefSeq, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:53998417-54121057
Strand Forward strand
Band C1
Transcripts
ENSMUST00000071083 ENSMUSP00000069272
ENSMUST00000117661 ENSMUSP00000113174
ENSMUST00000155608
ENSMUST00000152812 ENSMUSP00000118470
ENSMUST00000129109
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005246 calcium channel regulator activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0015279 store-operated calcium channel activity
Biological Process
GO:0006874 cellular calcium ion homeostasis
GO:0032237 activation of store-operated calcium channel activity
GO:0051928 positive regulation of calcium ion transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000109689
View Gene Order
ENSBTAG00000019353
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04020
Calcium signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04020
Calcium signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt P83093
TrEMBL A5CVE4 B2RQE3 B7ZN44 Q8C4Z8
UniProt Splice Variant
Entrez Gene 116873
UniGene Mm.265985 Mm.397177 Mm.401540 Mm.404062
RefSeq NM_001081103 XM_006503682
OMIM
CCDS CCDS39089
HPRD
IMGT
MGI ID MGI:2151156
MGI Symbol Stim2
EMBL AF328907 AK080310 AK173183 AM712359 BC043455 BC137881 BC145001 CH466524
GenPept AAH43455 AAI37882 AAI45002 AAK82339 BAC37875 BAD32461 CAN36430 EDL37685
RNA Seq Atlas 116873

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca