InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Stim2

Summary

InnateDB Protein

IDBP-400964.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stim2

Protein Name

stromal interaction molecule 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113174

InnateDB Gene

IDBG-164870 (Stim2)

Protein Structure

UniProt Annotation

Function

Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Dynamically translocates from a uniform endoplasmic reticulum distribution to punctual endoplasmic reticulum-plasma membrane junctions in response to decrease in endoplasmic reticulum Ca(2+) concentration. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005246	calcium channel regulator activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0015279	store-operated calcium channel activity

Biological Process

GO:0006874	cellular calcium ion homeostasis
GO:0032237	activation of store-operated calcium channel activity
GO:0051928	positive regulation of calcium ion transport
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:2151156

InterPro

IPR001660 Sterile alpha motif domain
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR021129 Sterile alpha motif, type 1

PFAM

PF07647
PF00536

PRINTS

PIRSF

SMART

SM00454

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P83093