Version 5.4
Mus musculus Gene: Tm2d1
Summary
InnateDB Gene IDBG-165036.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tm2d1
Gene Name TM2 domain containing 1
Synonyms 2310026L18Rik; AA990549; Bbp
Species Mus musculus
Ensembl Gene ENSMUSG00000028563
Encoded Proteins
IDBP-165038
TM2 domain containing 1
IDBP-165040
TM2 domain containing 1
IDBP-267488
TM2 domain containing 1
IDBP-534288
TM2 domain containing 1
IDBP-541554
TM2 domain containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162604:
The protein encoded by this gene is a beta-amyloid peptide-binding protein. It contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily and known to be important in heterotrimeric G protein activation. Beta-amyloid peptide has been established to be a causative factor in neuron death and the consequent diminution of cognitive abilities observed in Alzheimer's disease. This protein may be a target of neurotoxic beta-amyloid peptide, and may mediate cellular vulnerability to beta-amyloid peptide toxicity through a G protein-regulated program of cell death. [provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:98355370-98383306
Strand Reverse strand
Band C6
Transcripts
ENSMUST00000102793 ENSMUSP00000099855
ENSMUST00000030292 ENSMUSP00000030292
ENSMUST00000107051 ENSMUSP00000102666
ENSMUST00000125034 ENSMUSP00000124188
ENSMUST00000143116 ENSMUSP00000121468
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001540 beta-amyloid binding
GO:0004930 G-protein coupled receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005887 integral component of plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000162604
View Gene Order
ENSBTAG00000017161
Not yet available
Cross-References
SwissProt Q99MB3
TrEMBL
UniProt Splice Variant
Entrez Gene 94043
UniGene
RefSeq NM_053157 XM_006503494
OMIM
CCDS CCDS18374
HPRD
IMGT
MGI ID MGI:2137022
MGI Symbol Tm2d1
EMBL AF353993 AK009511 AL671140 BC089492
GenPept AAH89492 AAK35067 CAM26981 CAM26983 CAM26984
RNA Seq Atlas 94043

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca