Version 5.4
Mus musculus Gene: Map4k1
Summary
InnateDB Gene IDBG-165254.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Map4k1
Gene Name mitogen-activated protein kinase kinase kinase kinase 1
Synonyms Hpk1; mHPK1
Species Mus musculus
Ensembl Gene ENSMUSG00000037337
Encoded Proteins
IDBP-165256
mitogen-activated protein kinase kinase kinase kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104814:
Gene Information
Type Protein coding
Genomic Location Chromosome 7:28982854-29003279
Strand Forward strand
Band B1
Transcripts
ENSMUST00000085835 ENSMUSP00000082995
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005083 small GTPase regulator activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008349 MAP kinase kinase kinase kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0000165 MAPK cascade
GO:0000185 activation of MAPKKK activity
GO:0006468 protein phosphorylation
GO:0006950 response to stress
GO:0008283 cell proliferation
GO:0018105 peptidyl-serine phosphorylation
GO:0035556 intracellular signal transduction
GO:0046777 protein autophosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000104814
View Gene Order
ENSBTAG00000021145
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04010
MAPK signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
REACTOME
KEGG
hsa04010
MAPK signaling pathway pathway
INOH
PID NCI
tcr_pathway
TCR signaling in naïve CD4+ T cells
bcr_5pathway
BCR signaling pathway
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
tcrjnkpathway
JNK signaling in the CD4+ TCR pathway
Cross-References
SwissProt P70218
TrEMBL
UniProt Splice Variant
Entrez Gene 26411
UniGene Mm.148278 Mm.488834
RefSeq NM_008279 XM_006539997
OMIM
CCDS CCDS39865
HPRD
IMGT
MGI ID MGI:1346882
MGI Symbol Map4k1
EMBL BC005433 BC024832 Y09010
GenPept AAH05433 AAH24832 CAA70213
RNA Seq Atlas 26411

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca