Version 5.4
Homo sapiens Gene: MAP4K1
Summary
InnateDB Gene IDBG-49296.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAP4K1
Gene Name mitogen-activated protein kinase kinase kinase kinase 1
Synonyms HPK1
Species Homo sapiens
Ensembl Gene ENSG00000104814
Encoded Proteins
IDBP-236612
mitogen-activated protein kinase kinase kinase kinase 1
IDBP-765410
IDBP-765512
IDBP-761464
IDBP-763595
IDBP-761890
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 19:38587641-38618882
Strand Reverse strand
Band q13.2
Transcripts
ENST00000396857 ENSP00000380066
ENST00000592225
ENST00000588938
ENST00000591517 ENSP00000465039
ENST00000591210
ENST00000587300
ENST00000593196
ENST00000588083
ENST00000592888
ENST00000591707
ENST00000585583 ENSP00000468396
ENST00000589002
ENST00000589130 ENSP00000468164
ENST00000591921 ENSP00000465303
ENST00000586296 ENSP00000465774
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 47 [view]
Protein-Protein 46 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005083 small GTPase regulator activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008349 MAP kinase kinase kinase kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0000185 activation of MAPKKK activity
GO:0006468 protein phosphorylation
GO:0006950 response to stress
GO:0007257 activation of JUN kinase activity
GO:0008283 cell proliferation
GO:0018105 peptidyl-serine phosphorylation
GO:0035556 intracellular signal transduction
GO:0046777 protein autophosphorylation
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037337
View Gene Order
ENSBTAG00000021145
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
REACTOME
KEGG
hsa04010
MAPK signaling pathway pathway
INOH
PID NCI
tcr_pathway
TCR signaling in naïve CD4+ T cells
bcr_5pathway
BCR signaling pathway
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
tcrjnkpathway
JNK signaling in the CD4+ TCR pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.95424
RefSeq NM_001042600 NM_007181 XM_006722993
HUGO
OMIM
CCDS CCDS42564 CCDS59385
HPRD 03583
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca