InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tinf2

Summary

InnateDB Gene

IDBG-165275.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tinf2

Gene Name

Terf1 (TRF1)-interacting nuclear factor 2

Synonyms

AW552114; D14Wsu146e; Tin2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000007589

Encoded Proteins

IDBP-165279

Terf1 (TRF1)-interacting nuclear factor 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000092330:
This gene encodes one of the proteins of the shelterin, or telosome, complex which protects telomeres by allowing the cell to distinguish between telomeres and regions of DNA damage. The protein encoded by this gene is a critical part of shelterin; it interacts with the three DNA-binding proteins of the shelterin complex, and it is important for assembly of the complex. Mutations in this gene cause dyskeratosis congenita (DKC), an inherited bone marrow failure syndrome. [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:55679083-55681817

Strand

Reverse strand

Band

Transcripts

ENSMUST00000007733

ENSMUSP00000007733

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 86 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	86 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042162	telomeric DNA binding

Biological Process

GO:0010833	telomere maintenance via telomere lengthening
GO:0010836	negative regulation of protein ADP-ribosylation
GO:0032202	telomere assembly
GO:0032205	negative regulation of telomere maintenance
GO:0032206	positive regulation of telomere maintenance
GO:0032211	negative regulation of telomere maintenance via telomerase
GO:0034502	protein localization to chromosome
GO:0050680	negative regulation of epithelial cell proliferation
GO:0070198	protein localization to chromosome, telomeric region