Version 5.4
Bos taurus Gene: TINF2
Summary
InnateDB Gene IDBG-645709.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TINF2
Gene Name TERF1-interacting nuclear factor 2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000002718
Encoded Proteins
IDBP-698446
TERF1-interacting nuclear factor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000092330:
This gene encodes one of the proteins of the shelterin, or telosome, complex which protects telomeres by allowing the cell to distinguish between telomeres and regions of DNA damage. The protein encoded by this gene is a critical part of shelterin; it interacts with the three DNA-binding proteins of the shelterin complex, and it is important for assembly of the complex. Mutations in this gene cause dyskeratosis congenita (DKC), an inherited bone marrow failure syndrome. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:20760139-20763063
Strand Forward strand
Band
Transcripts
ENSBTAT00000003522 ENSBTAP00000003522
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 80 interaction(s) predicted by orthology.
Predicted by orthology
Total 80 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042162 telomeric DNA binding
Biological Process
GO:0010833 telomere maintenance via telomere lengthening
GO:0010836 negative regulation of protein ADP-ribosylation
GO:0032202 telomere assembly
GO:0032205 negative regulation of telomere maintenance
GO:0032206 positive regulation of telomere maintenance
GO:0032211 negative regulation of telomere maintenance via telomerase
GO:0034502 protein localization to chromosome
GO:0050680 negative regulation of epithelial cell proliferation
GO:0070198 protein localization to chromosome, telomeric region
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0000783 nuclear telomere cap complex
GO:0005634 nucleus
GO:0010370 perinucleolar chromocenter
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000092330
View Gene Order
ENSMUSG00000007589
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75792
Meiotic synapsis pathway
REACT_7963
Packaging Of Telomere Ends pathway
REACT_120956
Cellular responses to stress pathway
REACT_22172
Chromosome Maintenance pathway
REACT_7970
Telomere Maintenance pathway
REACT_115566
Cell Cycle pathway
REACT_169185
DNA Damage/Telomere Stress Induced Senescence pathway
REACT_169274
Cellular Senescence pathway
REACT_111183
Meiosis pathway
KEGG
INOH
PID NCI
telomerasepathway
Regulation of Telomerase
Cross-References
SwissProt
TrEMBL A3KN17 A7E3R3
UniProt Splice Variant
Entrez Gene 540420
UniGene
RefSeq
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC133484 BT030684 DAAA02028029
GenPept AAI33485 ABS45000
RNA Seq Atlas 540420

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca