InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tgm1

Summary

InnateDB Gene

IDBG-165378.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tgm1

Gene Name

transglutaminase 1, K polypeptide

Synonyms

2310004J08Rik; Tgase1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022218

Encoded Proteins

IDBP-165380

transglutaminase 1, K polypeptide

IDBP-620266

transglutaminase 1, K polypeptide

IDBP-716497

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000092295:
The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE). [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3\' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:55700009-55713492

Strand

Reverse strand

Band

Transcripts

ENSMUST00000002389	ENSMUSP00000002389
ENSMUST00000168729	ENSMUSP00000128090
ENSMUST00000178034	ENSMUSP00000137642

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003810	protein-glutamine gamma-glutamyltransferase activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0009887	organ morphogenesis
GO:0018149	peptide cross-linking
GO:0019538	protein metabolic process
GO:0030216	keratinocyte differentiation
GO:0031424	keratinization

Cellular Component

GO:0005913	cell-cell adherens junction
GO:0031224	intrinsic component of membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000092295

View Gene Order

ENSBTAG00000003920

Not yet available

Cross-References

SwissProt

Q9JLF6

TrEMBL

UniProt Splice Variant

Entrez Gene

21816

UniGene

Mm.41964

RefSeq

NM_001161714 NM_001161715 NM_019984 XM_006518806 XM_006518807 XM_006518808 XM_006518809

OMIM

CCDS

CCDS36932

HPRD

IMGT

MGI ID

MGI:98730

MGI Symbol

Tgm1

EMBL

AF186373 BC026422

GenPept

AAF35986 AAH26422

RNA Seq Atlas

21816