Version 5.4
Mus musculus Protein: Tgm1
Summary
InnateDB Protein IDBP-165380.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tgm1
Protein Name transglutaminase 1, K polypeptide
Synonyms 2310004J08Rik; Tgase1;
Species Mus musculus
Ensembl Protein ENSMUSP00000002389
InnateDB Gene IDBG-165378 (Tgm1)
Protein Structure
UniProt Annotation
Function Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross- linking epidermal proteins during formation of the stratum corneum (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in large amounts in epithelial tissues (lung, liver and kidney). {ECO:0000269PubMed:10567386}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003810 protein-glutamine gamma-glutamyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0009887 organ morphogenesis
GO:0018149 peptide cross-linking
GO:0019538 protein metabolic process
GO:0031424 keratinization
Cellular Component
GO:0005913 cell-cell adherens junction
GO:0031224 intrinsic component of membrane
Protein Structure and Domains
PDB ID MGI:98730
InterPro IPR001102 Transglutaminase, N-terminal
IPR002931 Transglutaminase-like
IPR008958 Transglutaminase, C-terminal
IPR014756 Immunoglobulin E-set
PFAM PF00868
PF01841
PF00927
PRINTS
PIRSF
SMART SM00460
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JLF6
PhosphoSite PhosphoSite-Q9JLF6
TrEMBL
UniProt Splice Variant
Entrez Gene 21816
UniGene Mm.41964
RefSeq NP_064368
MGI ID
MGI Symbol Tgm1
OMIM
CCDS CCDS36932
HPRD
IMGT
EMBL AF186373 BC026422
GenPept AAF35986 AAH26422

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca