Version 5.4
Mus musculus Gene: Aco2
Summary
InnateDB Gene IDBG-165439.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Aco2
Gene Name aconitase 2, mitochondrial
Synonyms Aco-2; Aco3; D10Wsu183e
Species Mus musculus
Ensembl Gene ENSMUSG00000022477
Encoded Proteins
IDBP-165441
aconitase 2, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100412:
The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:81872309-81915133
Strand Forward strand
Band E1
Transcripts
ENSMUST00000023116 ENSMUSP00000023116
ENSMUST00000157003
ENSMUST00000135198
ENSMUST00000126352
ENSMUST00000155704
ENSMUST00000144324
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003994 aconitate hydratase activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0051538 3 iron, 4 sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006099 tricarboxylic acid cycle
GO:0006101 citrate metabolic process
GO:0006102 isocitrate metabolic process
GO:0008152 metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000100412
View Gene Order
ENSBTAG00000006429
Not yet available
Pathways
NETPATH
REACTOME
REACT_189162
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_188937
Metabolism pathway
REACT_241308
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
REACT_249033
Citric acid cycle (TCA cycle) pathway
KEGG
mmu00020
Citrate cycle (TCA cycle) pathway
mmu00630
Glyoxylate and dicarboxylate metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_118595
Mitochondrial protein import pathway
REACT_1785
Citric acid cycle (TCA cycle) pathway
REACT_1046
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
REACT_17015
Metabolism of proteins pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
REACT_215469
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_219139
Metabolism pathway
REACT_220485
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
REACT_227707
Citric acid cycle (TCA cycle) pathway
KEGG
hsa00020
Citrate cycle (TCA cycle) pathway
hsa00630
Glyoxylate and dicarboxylate metabolism pathway
INOH
INOH website
Citrate cycle pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_080633
OMIM
CCDS CCDS27675
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca