InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ACO2

Summary

InnateDB Gene

IDBG-641912.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACO2

Gene Name

Aconitate hydratase, mitochondrial

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006429

Encoded Proteins

IDBP-694324

Aconitate hydratase, mitochondrial

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100412:
The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:113089139-113138185

Strand

Forward strand

Band

Transcripts

ENSBTAT00000008431

ENSBTAP00000008431

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003994	aconitate hydratase activity
GO:0005506	iron ion binding
GO:0016829	lyase activity
GO:0046872	metal ion binding
GO:0051536	iron-sulfur cluster binding
GO:0051539	4 iron, 4 sulfur cluster binding