InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GABRA4

Summary

InnateDB Gene

IDBG-16546.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GABRA4

Gene Name

gamma-aminobutyric acid (GABA) A receptor, alpha 4

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000109158

Encoded Proteins

IDBP-16550

gamma-aminobutyric acid (GABA) A receptor, alpha 4

IDBP-478254

gamma-aminobutyric acid (GABA) A receptor, alpha 4

IDBP-477637

gamma-aminobutyric acid (GABA) A receptor, alpha 4

IDBP-478760

gamma-aminobutyric acid (GABA) A receptor, alpha 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.[provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:46918900-46994407

Strand

Reverse strand

Band

p12

Transcripts

ENST00000264318	ENSP00000264318
ENST00000511523	ENSP00000422152
ENST00000508560	ENSP00000425445
ENST00000502874	ENSP00000424386
ENST00000509316

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004890	GABA-A receptor activity
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005254	chloride channel activity
GO:0008503	benzodiazepine receptor activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0007214	gamma-aminobutyric acid signaling pathway
GO:0007268	synaptic transmission
GO:0007417	central nervous system development
GO:0034220	ion transmembrane transport
GO:0055085	transmembrane transport
GO:1902476	chloride transmembrane transport
GO:2001023	regulation of response to drug

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0034707	chloride channel complex
GO:0045211	postsynaptic membrane